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Cryptococcus
Pseudoepitheliomatous hyperplasia with/without ulceration
  • Suppurative and granulomatous inflammation with round yeasts (2-10 microns), free and within giant cells.

  • This fungus is common in soil and pigeon droppings
  • Infection can rarely be due to primary inoculation as ulcerated lesions or cellulitis
  • More common is dissemination from the lungs presenting as papules, pustules, nodules, herpetiform lesions, or subcutaneous nodules
  • In AIDs, head and neck lesions are most common, often resembling molluscum contagiosum