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This histologic subtype of seborrheic keratosis typically has a flat plaque-like appearance with horn cysts
  • Broad sheets of small polygonal keratinocytes which look monotonous throughout the lesion
  • Scattered horn cysts
  • Loose lamellar stratum corneum
  • Scattered pigment.
  • Work-Up Considerations:

    • Seborrheic keratoses can usually be diagnosed clinically
    • However, any lesions suspicious for skin cancer should be biopsied for histologic evaluation

    Treatment:

    • This is a benign lesion
    • Additional therapy after confirmation of diagnosis is not medically necessary
    • Removal for cosmetic purposes can be achieved by cryotherapy and/or curettage, and other methods, including chemical peels, ablative laser therapy, and surgical removal.
    • Sudden appearance of multiple seborrheic keratoses in adult patients may signal an underlying internal malignancy (Leser-Tr?lat sign).
    Sudden appearance of multiple seborrheic keratoses in adult patients may signal an underlying internal malignancy (Leser-Trélat sign).
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